This study presents a physiologically detailed biomechanical model of the mouse distal forelimb that incorporates intrinsic musculature, tendon routing, and digit-level skeletal anatomy, features simplified or omitted in existing musculoskeletal models. Using high-resolution anatomical reconstruction and computational modeling, we created a physiological representation of the wrist and digits capable of simulating complex forelimb movements. The model enables simulation of coordinated distal forelimb movement and digit-level muscle behavior during grasping-related tasks. Simulations were performed for multiple tasks, including grasping, grasping with supination, wrist flexion, and digit I flexion, with analysis focused on the grasping task due to its integration of both intrinsic and extrinsic musculature. Model performance was evaluated through comparisons of marker trajectories between torque-driven reference motion and muscle-driven simulations, temporal shuffle control, and comparisons between experimentally recorded electromyography (EMG) activity and model-predicted muscle excitation profiles. The model successfully reproduced coordinated distal forelimb kinematics, demonstrated strong agreement between torque-driven and muscle-driven simulation approaches, and generated physiologically plausible muscle excitation patterns consistent with experimentally observed EMG activity during grasping-related movement. These findings establish the model as a framework for studying fine motor control, neuromuscular coordination, and movement-related impairments in mice while providing a foundation for future investigation of neurological disorders and their underlying biomechanical mechanisms.
Lindo Sandoval, N., Gilmer, J. I., Al Borno, M., Cuenu Velasco, A. G., Huber, D.
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