Ageing alters brain rhythms and large-scale functional organisation, but whether these changes reflect isolated effects or a coordinated reconfiguration remains unclear. We applied Frequency-resolved Network Estimation via Source Separation (FREQ-NESS) to source-reconstructed resting-state MEG from 164 healthy younger and older adults across two independent datasets. FREQ-NESS revealed that ageing reshaped the frequency-resolved organisation of whole-brain networks. Older adults showed a slower alpha-network peak and a flatter decay of network prominence from alpha into beta frequencies, together with changes in entropy across the spectrum. These spectral changes were accompanied by shifts in the spatial expression of dominant networks along the lateral, posterior-anterior, and inferior-superior spatial axes. Rather than following a uniform anatomical shift, the direction of age differences varied across frequencies. Together, these findings show that healthy ageing is associated with a reshaped configuration of endogenous brain networks, characterised not simply by a uniform loss of network organisation, but by selective reconfiguration of the prominence and spatiotemporal expression of whole-brain activity across frequencies.
Kudriavtsev, N., Rosso, M., Fernandez-Rubio, G., Serra, E., Houe Andersen, M., Kringelbach, M. L., Vuust, P., Bonetti, L.
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