Scientific & Computational Responsibilities:
- Lead unbiased, data-driven integration of:
- Spatial transcriptomics data
- Genomic alteration profiles (copy number alterations, SNVs)
- Histopathological diagnoses and clinical metadata
- Radiomic features (in collaboration with imaging specialists)
- Perform unsupervised clustering and pattern discovery without predefined diagnostic labels
- Interpret molecular and microenvironmental states of benign, premalignant, and malignant pulmonary nodules
- Identify and prioritize biomarkers for:
- Liquid biopsy development
- PET tracer target discovery
- Contribute to validation strategies (e.g. immunohistochemistry) in collaboration with pathologists
- Lead the preparation of high-impact, interdisciplinary publications
Translational & Collaborative Responsibilities:
- Act as a scientific integrator across multiple collaborating research groups
- Communicate effectively with clinicians, pathologists, imaging scientists, and molecular technologists
- Maintain reproducible and well-documented analysis workflows
Patient Engagement & Return-of-Data Work Package:
- Actively participate in a participant-driven co-design process to develop a framework for returning molecular and imaging data to study participants
- Contribute scientific content to patient workshops and plain-language communication materials
- Co-facilitate workshops together with ethicists, communication experts, and institutional partners
- Help synthesize participant feedback into structured outputs, including:
- A return-of-data blueprint
- Prototype participant reports
- An evaluated framework for future implementation
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