TLS-Sim: An Open-Source Toolkit for Individualized Transcranial Light Stimulation Modeling with Deep-Learning-Accelerated Simulation

Background: Accurate modeling of photon transport through the heterogeneous tissues of the human head is important for individualized transcranial light stimulation (tLS). However, high-precision Monte Carlo (MC) simulations can be computationally demanding, and existing general-purpose simulation tools do not provide an integrated, brain-oriented workflow. Methods: We developed TLS-Sim, a framework that integrates subject-specific head-model construction, multiple light-source configuration, GPU-accelerated MC photon simulation, visualization, and intracranial dosimetric analysis. Its central feature is a deep-learning-accelerated MC pathway, termed Flux-to-Flux, that estimates a high-photon-count energy-deposition field from a paired low-photon-count simulation. Sparse and full Monte Carlo fields were encoded using a three-dimensional variational autoencoder (VAE), and a three-dimensional velocity network was trained to transform the sparse latent representation toward the corresponding full-simulation representation. Results: We demonstrate the end-to-end toolkit and the Flux-to-Flux (F2F) pathway on a representative individualized head model evaluated across three source configurations. Relative to the sparse simulation, the learned prediction improved agreement with the full Monte Carlo reference by approximately +4 dB in signal-to-noise ratio on average, with correspondingly higher structural similarity and lower mean absolute error. Conclusions: TLS-Sim provides a modular, openly released computational framework for individualized tLS simulation and analysis. The Flux-to-Flux pathway is presented as an implemented capability that reduces the computational burden of high-photon-count simulation while improving spatial agreement with the full MC reference, most strongly at the low-fluence field boundaries where the sparse simulation is noisiest.

Zhang, K., Jia, H., Li, Z., Wang, S., Zhang, Y., Cong, F., Cui, Z., Li, X., Zhao, C.

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