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Antimicrobial stewardship in low- and middle-income countries: Access versus adherence

Journal content Created on 28 Aug 2026 PLOS Medicine

by Kiarah Shchepanik, Anthony D. Bai, Heather Wise

Can improving access to antimicrobial guidelines improve prescriber adherence? In a recent study published in PLOS Medicine (the LAMPA trial), a smartphone app did not improve adherence despite enhanced access to guidelines, highlighting that prescriber behavior is complex, and effective antimicrobial stewardship interventions need to be multifaceted and sustained. This Perspective by Kiarah Shchepanik and colleagues discusses results from the recent LAMPA trial, in which a smartphone app did not improve adherence to antimicrobial prescriber guidelines despite enhanced access, and outline why multifaceted and sustained interventions are needed due to complex prescriber behavior.

Heather Wise

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