Neurological disorders are a major cause of death and disability worldwide. The brain's energy metabolism is essential to its proper function, yet the mechanisms driving neuroenergetic dysfunction remain poorly understood. A key challenge is the limited availability of human-relevant models that can reproduce the complexity of brain physiology. An Organ-on-Chip (OoC) system was developed to mimic the neurovascular unit metabolic coupling by incorporating human isogenic iPSC-derived endothelial-like cells, pericyte-like cells, astrocytes, and a cerebral organoid, representing the main cellular components of the NVU. The novel, customized microfluidic platform enables research on neurovascular coupling by interconnecting a blood-brain barrier-on-a-chip model with a 3D brain parenchymal compartment to mimic physiological conditions.
Ceballos Torres, A. P., Montesi, L., Loel, L., Yanovska, M., Venckute, J., Jessika, J., Wu, T., Benito Zarza, L., Cognetti, J., Fotouhi, O., Klavins, K., Ygberg, S., Wredenberg, A., Wedell, A., Herland, A., Rogal, J.
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