Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community. Job Summary The position is for a research scientist who will investigate and develop technologies for the synthesis and assembly of synthetic DNA molecules. Essential Job Duties Design and conduct experiments to investigate how to further scale the Sidewinder DNA assembly technology (30%) Develop bioinformatics pipelines for optimally orthogonal DNA sequence barcode generation with low computational cost Utilize DNA and Protein AI models for the procurement of target sequences for biologically, therapeutically, and industrially relevant targets Protocol development for increasing fidelity of the Sidewinder reaction with various DNA inputs Design and conduct experiments to investigate complementary DNA assembly technologies (30%) Design, plan, and execute experiments to investigate and optimize DNA assembly technologies, including USER cloning, Gibson assembly, Golden Gate assembly, and related molecular biology methods. Develop experimental protocols for DNA construct generation, ensuring reproducibility, efficiency, and high-quality results Collaborate with cross-functional research teams to design genetic constructs, evaluate novel assembly approaches, and support project objectives. Develop bioinformatic pipelines for the design and analysis of DNA sequences and assemblies (20%) Handle large sequencing datasets from Nanopore, Illumina, and PacBio Streamline analysis of Sidewinder assembly products assessing assembly quality at the base, junction, and assembly level. Prepare research reports and presentations for internal meetings, publications, and conferences (20%) Basic Qualifications PhD in biological sciences Detailed knowledge of Sidewinder DNA assembly, DNA sequencing methodologies, and molecular biology At least 3 years of experience performing biological experiments independently, including DNA sequencing and assembly Preferred Qualifications Experience mentoring undergraduates or graduate students Experience presenting at scientific meetings Required Documents Resume
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