High-resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications require instrumentation to be capable of combining sub-ppm mass accuracy, high resolving power, rapid full m/z range acquisition, and a wide dynamic range. Achieving these requirements simultaneously places constraints on analyzer design and performance. Multi-reflecting time-of-flight (MRT) based analyzers have been previously reported as a means of extending effective flight path length in compact TOF designs. Here, further instrument and functionality advances in a compact MRT mass spectrometer design are described and the impact of these enhancements is demonstrated for omics applications.
Wildgoose, J., Ferries, S., Gethings, L. A., Daly, M. E., Palmer, M. E., Lock, R., Vissers, J. P., Langridge, J. I.
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