The brain is the most captivating chef d'oeuvre of nature. Naturally then, the mind wonders about the process that births such a fascinating organ. Neurodevelopment is a complex yet robust phenomenon that conceals answers to our questions in its intricacies. In an attempt to shed some light on this matter, we study the developing brain connectome of the nematode, C. elegans across the post-embryonic phase. A tiny organism with only around 200 neurons comprising its brain and yet a diverse array of behaviors to display, it makes for a great model. Starting with most of its head neurons already present at hatching, the worm brain accumulates numerous more synaptic connections increasing the edge density. It maintains a weak connectivity throughout thereby, balancing global communication as well as hierarchy. At the mesoscopic level, we find that the core has a conserved backbone of persistent neurons along with a dynamic component formed of transient/recurring neurons. Moreover, the connectome has a rich club organization since the early stage which selectively strengthens indicating a progressively denser connectivity among the integrators due to the previously reported asymmetric synapse addition. This asymmetry also shows up in the preservation of input hubs across development and the progressively more centralized organization of the in-degree k-core. Our work provides a new perspective into the neurodevelopment of the brain that may facilitate our understanding of its functioning.
YADAV, P., Singh, A.
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