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STN-DBS frequency-tuned beta subband dynamics are associated with speech tempo in Parkinson's disease

Preprint Created on 11 Jun 2026 bioRxiv

In Parkinson's disease, subthalamic nucleus deep brain stimulation (STN-DBS) frequency modulated narrow beta subbands, with low-frequency stimulation (LFS) selectively attenuating 15-23 Hz power. The negative association between this subband and speech-tempo, together with LFS-related improvement in articulatory rate, suggests that 15-23 Hz subband dynamics may serve as a candidate neural marker of speech-tempo related modulation.

Tian, H., Wu, Y., Fan, Y., Yin, Z., Guo, Y., Meng, F., Zhang, J., Yu, H., Li, L.

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