The incidence of vascular complications differs among dermal filler formulations. This study aimed to evaluate the embolic risk associated with Neofilera(R), a filler composed of carboxymethyl cellulose and polylactic acid microspheres, following intra-arterial injection. The central auricular arteries of rabbits were injected with Neofilera(R) at volumes of 0.1 mL or 0.2 mL under various conditions: normal saline (control) and Neofilera(R) diluted at ratios of 1:5 (Group 1), 1:10 (Group 2), and 1:15 (Group 3). The presence of transparent emboli was assessed immediately after injection, while tissue necrosis (percentage and area) and histopathological alterations were evaluated on days 1 and 7 post-injection. Relative to controls, Neofilera(R) administered at 0.1 mL dispersed within minutes and did not induce significant tissue necrosis at either ob-servation time point. In contrast, administration of 0.2 mL, even in diluted form, was associated with an increased incidence of vascular occlusion. Overall, these findings indicate that Neofilera(R) presents a lower embolic risk when injected at a volume of 0.1 mL, whereas higher injection volumes may substantially increase the likelihood of embolic complications.
Vachiramon, V., Boonyarattanasoonthorn, T., Duangbupha, J., Kijtawornrat, A., Liu, C.-C., Hsieh, C.-H.
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