Coronaviruses of the genus Gammacoronavirus cause major poultry diseases, including infectious bronchitis in chickens and enteritis in turkeys and guinea fowl. Until now, no enteric coronavirus distinct from infectious bronchitis virus had been reported in chickens. Between late 2024 and 2025, severe enteritis outbreaks affected broiler farms in southwestern France, causing increased mortality, wet litter, cyanosis, lethargy, ruffled feathers, and high slaughter condemnation rates. Necropsy and histopathology revealed diffuse enteritis and dehydration. Metagenomic sequencing identified abundant coronavirus reads as the only pathogenic viral signal. Whole-genome phylogeny showed a novel gammacoronavirus lineage closely related to guinea fowl coronavirus but distinct from infectious bronchitis virus and turkey coronavirus. Viral RNA was detected in enterocytes by RNAscope in situ hybridization, and electron microscopy revealed coronavirus-like particles. These findings describe a novel enteritis-associated coronavirus in broiler chickens (ChECoV), although the drivers of its host-range expansion into chickens remain to be elucidated.
DELPONT, M., Gaide, N., BLONDEL, V., CRISPO, M., LINARD, B., SECULA, A., WALCH, M., BORTOT, L., DURAND, E., FOURQUAUX, I., CORRAND, L., SOUBIES, S. M., Bessiere, P., CROVILLE, G., GUERIN, J.-L.
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