Length and time constants are foundational to the study of conduction in neurons and other biological cables but are exactly defined only for passive membranes. Here we define and derive exact length and time constants for propagating action potentials in unmyelinated axons. This derivation exploits specific instants during action potential conduction when the net transmembrane ionic current is zero, but axial current remains non-zero. At these instants, we define a curvature parameter, {kappa}, explore its determinants using computer modelling, demonstrate that it is the local real Laplace exponent of the action potential upstroke, and suggest practical approaches for its experimental measurement. From {kappa}, we define action potential length and time constants, {lambda}AP = 1/{surd}({kappa}racm) and {tau}AP = 1/{kappa}, and show that action potential propagation velocity is exactly {lambda}AP/{tau}AP.
Fraser, J. A., Lopez-Belmonte Deza, E.
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