Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments

We report here a method for the chemical synthesis of Fmoc-protected -hydroxyglyine (-OH-Gly) dipeptides. Our method features operational simplicity and is compatible with protecting groups for peptide synthesis. Utility is then demonstrated through substitution at the -OH-Gly position to yield myriad non-natural amino acid-containing dipeptide fragments.

Solanke, P. R., Sarkar, D., Saha, P. C., Taylor, M. T.

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