We propose a rigorous and reproducible methodology for analyzing functional MRI data, aimed at: (1) demonstrate their efficiency in classifying task-induced brain states with a limited amount of data, (2) present a methodology to identify brain regions critical for classification and reveal their uniqueness across different states, and (3) show, using strong mathematical methods, that the discriminative power of these regions depends not only on their spatial localization but also on their coordinated temporal activity. Through correlation and temporal structure analyses, we demonstrated that top-ranked regions exhibit stronger, more structured, and richer dependencies than low-ranked regions, underscoring the critical role of temporal dynamics in shaping distinct cognitive brain states. Our work addresses the need for a transparent, accessible, and interpretable framework for studying cognitive processes through neuroimaging data. We analyzed fMRI data from 587 healthy participants from the Human Connectome Project across seven cognitive tasks. Finally, we perform a detailed analysis of the identified brain regions to support further neuroscientific interpretation and discussion.
Kirova, V., Kadieva, D., Vlasenko, D., Ratnikov, F., Blank, I. B.
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