CDP-ribitol serves as an essential donor for D-ribitol-5-phosphate incorporation into bacterial and mammalian glycoconjugates. Here, we demonstrate the one-pot enzymatic synthesis of CDP-ribitol from the readily available precursor ribitol. We also explore the synthesis of bioorthogonally tagged derivatives and other CDP conjugates, thereby providing valuable new tools for glycoscience research.
Akkad, S., Wan, E. W., Maddison, A., Rule Mcloughlin, J., Au-Yeung, C., Murphy, L. D., Willems, L. I.
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